Abstract
For rapid and kinetic control-influenced resolutions, it is advisable to choose a resolving agent with the highest possible eutectic composition (eeEuResAg). It may also be advantageous to add the crystalline resolving agent directly to the solution of the racemic compound. In addition, the use of a quasi-racemic resolving agent or amphoteric resolving agent can provide kinetic resolution. In some cases, the continuous fractional crystallization of diastereomeric salts requires the salt of the resolving agent (Ca2+, Na+, etc.) or other achiral additives (thiourea) that cause rapid crystallization and provide high diastereomeric purity. A further advantage may be the sequential use of the same resolving agent that is capable of forming crystalline diastereomers with both enantiomers when using kinetic control (tandem resolution).
Subject
Physics and Astronomy (miscellaneous),General Mathematics,Chemistry (miscellaneous),Computer Science (miscellaneous)
Reference21 articles.
1. Löslichkeit und Schmelzpunkt als Kriterien für racemische Verbindungen, pseudoracemische Mischkrystalle und inaktive Konglomerate
2. Enantiomers, Racemates and Resolution;Jacques,1981
3. A quantitative approach to optical resolution
4. Prediction of the efficiency of diastereoisomer separation on the basis of the behaviour of enantiomeric mixtures
5. Influence of Helical Structured Supramolecular Associates and that of Eutectic Composition on the Distribution of Enantiomeric and Diastereomeric Mixtures between Phases;Pálovics;Chem. Bull. “POLITEHNICA” Univ. (Timisoara),2016
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