Affiliation:
1. Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202002, UP, India
Abstract
Redox homeostasis, a dynamic process ensuring a balance between cellular oxidizing and reducing reactions, is crucial for maintaining healthy cellular physiology and regulating many biological processes, requiring continuous monitoring and fine-tuning. Reactive species play a critical role in intra/intercellular signaling, and each cell has a specific system guarding cellular redox homeostasis. ROS signaling and oxidative stress are involved in cancer initiation and progression. However, the generation of reactive species beyond the threshold level inside the tumor microenvironment is considered one of the therapeutic approaches. Various studies have shown that some phytochemicals can target the redox homeostasis of the tumor microenvironment. Recent advances have focused on developing and introducing phytochemical interventions as favorable therapeutic options against cancer. However, studies have also suggested the “virtuous” and “evil” impacts of phytochemicals. Some phytochemicals enhance therapeutic efficacy by promoting intracellular oxidant accumulation. However, under certain conditions, some phytochemicals may harm the cellular microenvironment to promote cancer and tend to target different pathways for cancer initiation and development instead of targeting redox homeostasis. In this context, this review is focused on providing an overall understanding of redox homeostasis and intends to highlight the potential positive and negative impacts of phytochemicals in redox homeostasis and disease development. We also discuss the recent nanotechnology-based advancements in combating cancer development.
Subject
Organic Chemistry,Inorganic Chemistry,Electrochemistry,Chemistry (miscellaneous)
Reference110 articles.
1. Redox Signaling by Reactive Electrophiles and Oxidants;Parvez;Chem. Rev.,2018
2. The Complex Interplay between Antioxidants and ROS in Cancer;Harris;Trends Cell. Biol.,2020
3. Oxidative Stress and Cancer: Ingenta Connect;Klaunig;Curr. Pharm. Des.,2018
4. Khan, M.A., Singh, D., Fatma, H., Akhtar, K., Arjmand, F., Maurya, S.K., and Siddique, H.R. (2022). Antiandrogen enzalutamide induced genetic, cellular, and hepatic damages: Amelioration by triterpene Lupeol. Drug Chem. Toxicol., 1–12.
5. Antioxidant enzymes and cancer;Khan;Chin. J. Cancer Res.,2010
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