An Efficient and Eco-Friendly Procedure for Electrophilic Thiocyanation of Anilines and 1-(Substituted benzylidene)-2-phenyl Hydrazines-Reference-Cited by-同舟云学术

An Efficient and Eco-Friendly Procedure for Electrophilic Thiocyanation of Anilines and 1-(Substituted benzylidene)-2-phenyl Hydrazines

Published:2024-06-10 Issue:3 Volume:6 Page:476-488
ISSN:2624-8549
Container-title:Chemistry
language:en
Short-container-title:Chemistry

Author:

Mallikarjunaswamy A. M. M.¹,Kuruvalli Gouthami²,Syed Khajamohiddin³^ORCID,Reddy Vaddi Damodara²³,Nair Vipin A.⁴^ORCID

Affiliation:

1. Department of Chemistry, School of Applied Sciences, REVA University, Yelahanka, Bangalore 560064, Karnataka, India

2. Department of Biotechnology, School of Applied Sciences, REVA University, Yelahanka, Bangalore 560064, Karnataka, India

3. Department of Biochemistry and Microbiology, Faculty of Science, Agriculture and Engineering, University of Zululand, KwaDlangezwa 3886, South Africa

4. School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri Campus, Clappana, Kollam 690525, Kerala, India

Abstract

Thiocyanates form an important class of organic compounds commonly found in natural products that exhibit excellent antimicrobial activity. The electrophilic thiocyanation is one of the most effective methods of introducing a -SCN functional group to the parent organic molecule. In this work, we explored an eco-friendly and highly efficient method for thiocyanation of anilines and 1-(substituted benzylidene)-2-phenylhydrazines using commercially available N-bromoscuccinimide (NBS) and potassium thiocyanate (KSCN). The optimized protocol afforded thiocyanates with good regioselectivity and excellent yields in comparison to the available methods.

Funder

University of Zululand

Publisher

MDPI AG

Link

https://www.mdpi.com/2624-8549/6/3/27/pdf

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