Corona-Associated Mucormycosis: Case Series Reports and Review of the Literature

Author:

Fitero Andreea12,Negrut Nicoleta12ORCID,John Harrie Toms3ORCID,Ferician Anca4,Marian Paula4

Affiliation:

1. Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania

2. Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania

3. Department of Ear, Nose and Throat, University Hospitals of Northamptonshire, Cliftonville, Northampton NN1 5BD, UK

4. Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania

Abstract

During the COVID-19 pandemic, a significant increase in cases of mucormycosis was observed in COVID-19 patients, especially in India, but not exclusively. The presented cases highlight the heterogeneous nature of mucormycosis, emphasizing the importance of recognizing predisposing factors, such as immunosuppression, due to comorbidities or medication. Diagnosing mucormycosis poses a challenge due to nonspecific clinical manifestations, requiring a multidisciplinary approach for accurate diagnosis. Treatment involves a multi-pronged approach centered around the early initiation of antifungal therapy alongside surgical intervention and the management of underlying conditions, with an emphasis on controlling immunosuppression. Understanding the relationship between COVID-19 and predisposing factors for mucormycosis is fundamental for developing prevention and treatment strategies.

Publisher

MDPI AG

Reference46 articles.

1. (2024, January 12). Centers for Disease Control and Prevention, Available online: https://www.cdc.gov/fungal/diseases/mucormycosis/definition.html.

2. Hernández, J.L., and Buckley, C.J. (2024). StatPearls, StatPearls Publishing LLC.

3. Alqarihi, A., Kontoyiannis, D.P., and Ibrahim, A.S. (2023). Mucormycosis in 2023: An update on pathogenesis and management. Front. Cell. Infect. Microbiol., 13.

4. Mucormycosis;Sugar;Clin. Infect. Dis.,1992

5. Anand, T., Mukherjee, A., Satija, A., Velamuri, P.S., Singh, K.J., Das, M., Josten, K., Yadav, P.D., Sahay, R.R., and Keche, A.Y. (2022). A case control investigation of COVID-19 associated mucormycosis in India. BMC Infect. Dis., 22.

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