Affiliation:
1. Organic Chemistry Department and Institute of Organic Synthesis (ISO), University of Alicante, Crta. San Vicente del Raspeig s/n, 03690 San Vicente del Raspeig, Alicante, Spain
Abstract
The study of new catalytic protocols for the synthesis of organic compounds with a more sustainable perspective is of interest. The use of ionic organic solids, such as 1,3-bis(carboxymethyl)imidazolium chloride as a catalyst has allowed the Michael addition of N-heterocycles to chalcones. This methodology has been applied to the unique preparation of the potential bioactive compound 1-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1-one with moderate yield, due to the retro-Michael reaction. Both synthetic reactions (i.e., preparation of chalcone and triazole Michael-addition to chalcone) have good green metrics.
Funder
Ministerio de Ciencia e Innovación
University of Alicante
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