Author:
Fox Brandon M.,Janssen Andrew,Estevez-Ordonez Dagoberto,Gessler Florian,Vicario Nunzio,Chagoya Gustavo,Elsayed Galal,Sotoudeh Houman,Stetler William,Friedman Gregory K.,Bernstock Joshua D.
Abstract
Protein SUMOylation is a dynamic post-translational modification which is involved in a diverse set of physiologic processes throughout the cell. Of note, SUMOylation also plays a role in the pathobiology of a myriad of cancers, one of which is glioblastoma (GBM). Accordingly, herein, we review core aspects of SUMOylation as it relates to GBM and in so doing highlight putative methods/modalities capable of therapeutically engaging the pathway for treatment of this deadly neoplasm.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Cited by
13 articles.
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