Abstract
Broad antiviral activity in vitro is known for many organic photosensitizers generating reactive oxygen species under irradiation with visible light. Low tissue penetration of visible light prevents further development of antiviral therapeutics based on these compounds. One possible solution to this problem is the development of photosensitizers with near-infrared absorption (NIR dyes). These compounds found diverse applications in the photodynamic therapy of tumors and bacterial infections, but they are scarcely mentioned as antivirals. In this account, we aimed to evaluate the therapeutic prospects of various NIR-absorbing and singlet oxygen-generating chromophores for the development of broad-spectrum photosensitizing antivirals.
Funder
Ministry of Science and Higher Education of the Russian Federation
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference159 articles.
1. Local treatment of viral disease using photodynamic therapy;Wainwright;Int. J. Antimicrob. Agents,2003
2. Photoinactivation of viruses;Wainwright;Photochem. Photobiol. Sci.,2004
3. Photodynamic inactivation of mammalian viruses and bacteriophages;Costa;Viruses,2012
4. Kunstek, H., Vreken, F., Keita, A., Hamblin, M.R., Dumarçay, F., and Varbanov, M. (2022). Aspects of antiviral strategies based on different phototherapy approaches: Hit by the light. Pharmaceuticals, 15.
5. Photodynamic treatment of pathogens;Delcanale;Riv. Nuovo Cimento,2022
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献