Abstract
3-(4-Nitrophenyl)-8-(2,3-dimethylphenyl)-7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-one (NDIT) is one of the most promising candidates for anticancer agents. Hence, a sensitive and selective sodium dodecyl sulfate-modified screen-printed carbon sensor (SPCE/SDS) was used for its quantitative analysis. The SPCE/SDS, in contrast to the SPCE, showed excellent behavior in the electrochemical reduction of NDIT by differential-pulse adsorptive stripping voltammetry (DPAdSV). Cyclic voltammetric (CV) studies reveal an irreversible, two-stage and not purely diffusion-controlled reduction process in 0.01 M HNO3. The sensor was characterized by CV and electrochemical impedance spectroscopy (EIS). Under the optimized conditions (t 45 s, ΔE 175 mV, ν 150 mV/s, and tm 5 ms), the DPAdSV procedure with the SPCE/SDS presented a very wide linear range from 1 to 2000 nM and a low detection limit of 0.29 nM. A 1000-fold excess concentration of potential interferents commonly present in biological samples did not significantly alter the peak current of NDIT. The practical application of the proposed DPAdSV procedure with the SPCE/SDS was successfully checked by analyzing spiked human serum samples.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference32 articles.
1. Synthesis, structure elucidation, determination of antiproliferative activities, lipophilicity indices and pharmacokinetic properties of novel fused azaisocytosine-containing congeners;Sztanke;Arab. J. Chem.,2019
2. Sztanke, M., and Sztanke, K. (2017). Derivatives of 3-(4-nitrophenyl)-7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-one Substituted by phenyl, alkylphenyl, dialkylphenyl and alkoxyphenyl, Method for Obtaining Them and Medical Application. (Polish Patent PL 225419).
3. Voltammetric generation and kinetic stability of nitro anion radical from nitrofurazone in ionic liquids;Chiavassa;J. Braz. Chem. Soc.,2021
4. Decomposition mechanism of annelated triazinones bearing the para-nitrophenyl group;Worzakowska;J. Anal. Appl. Pyrolysis,2020
5. Screen-printed graphite electrode modified with Co3O4 nanoparticles and 2D graphitic carbon nitride as an effective electrochemical sensor for 4-aminophenol detection;Jahani;Nanotechnology,2022
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献