The Application of Biomaterials in Spinal Cord Injury

Author:

Feng Chi,Deng Lan,Yong Yuan-Yuan,Wu Jian-MingORCID,Qin Da-Lian,Yu Lu,Zhou Xiao-Gang,Wu An-Guo

Abstract

The spinal cord and the brain form the central nervous system (CNS), which is the most important part of the body. However, spinal cord injury (SCI) caused by external forces is one of the most difficult types of neurological injury to treat, resulting in reduced or even absent motor, sensory and autonomic functions. It leads to the reduction or even disappearance of motor, sensory and self-organizing nerve functions. Currently, its incidence is increasing each year worldwide. Therefore, the development of treatments for SCI is urgently needed in the clinic. To date, surgery, drug therapy, stem cell transplantation, regenerative medicine, and rehabilitation therapy have been developed for the treatment of SCI. Among them, regenerative biomaterials that use tissue engineering and bioscaffolds to transport cells or drugs to the injured site are considered the most promising option. In this review, we briefly introduce SCI and its molecular mechanism and summarize the application of biomaterials in the repair and regeneration of tissue in various models of SCI. However, there is still limited evidence about the treatment of SCI with biomaterials in the clinic. Finally, this review will provide inspiration and direction for the future study and application of biomaterials in the treatment of SCI.

Funder

National Natural Science Foundation of China

Department of Science and Technology of Sichuan Province, China

Macao Science and Technology Development Fund of Macao SAR

Southwest Medical University

Luzhou Science and Technology Project, China

joint project of Luzhou Municipal People’s Government and Southwest Medical University

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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