Abstract
Melanoma is one of the most aggressive and progressive skin cancers. It develops from normal pigment-producing cells known as melanocytes, so it is important to know the mechanism behind such transformations. The study of metastasis mechanisms is crucial for a better understanding the biology of neoplastic cells. Metastasis of melanoma, or any type of cancer, is a multi-stage process in which the neoplastic cells leave the primary tumour, travel through the blood and/or lymphatic vessels, settle in distant organs and create secondary tumours. MicroRNA (miRNA) can participate in several steps of the metastatic process. This review presents the role of miRNA molecules in the development and progression as well as the immune response to melanoma.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference105 articles.
1. Microenvironmental regulation of tumor progression and metastasis;Quail;Nat. Med.,2013
2. New highlights on stroma–epithelial interactions in breast cancer;Medina;Breast Cancer Res.,2005
3. Molecular repair, wound healing, and carcinogenesis: Tumor production a possible overhealing?;Haddow;Adv. Cancer Res.,1972
4. Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing;Dvorak;N. Engl. J. Med.,1986
5. Reprograming Carcinoma Associated Fibroblasts by microRNAs;Xu;Curr. Mol. Med.,2017
Cited by
30 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献