Abstract
MicroRNAs (miRNAs) act as master regulators of gene expression in homeostasis and disease. Despite the rapidly growing body of evidence on the theranostic potential of restoring miRNA levels in pre-clinical models, the translation into clinics remains limited. Here, we review the current knowledge of miRNAs as T-cell targeting immunotherapeutic tools, and we offer an overview of the recent advances in miRNA delivery strategies, clinical trials and future perspectives in RNA interference technologies.
Funder
Spanish Ministry of Economy and Competitiveness
Comunidad de Madrid
Instituto de Salud Carlos “la Caixa”
AECC-Coordinated
Ministerio de Ciencia, Innovacion y Universidades
‘Severo Ochoa’ Programme for Centres of Excellence in R&D
Spanish Ministry of Universities
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Cited by
7 articles.
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