Abstract
Little is known about alternative treatment options for rhinosinusitis (RS). We aimed to evaluate the efficacy of low-level laser therapy (LLLT) for RS in experimentally induced rabbit models of RS. A total of 18 rabbits were divided into four groups: a negative control group (n = 3), an RS group without treatment (n = 5, positive control group), an RS group with natural recovery (n = 5, natural recovery group), and an RS group with laser irradiation (n = 5, laser-treated group). Computed tomography and histopathological staining were performed for each group. mRNA and protein expression levels of local cytokines (IFN-γ, IL-17, and IL-5) were also measured. Tissue inflammation revealed a significant improvement in the laser-treated group compared with the RS and natural recovery groups (p < 0.01). In addition, sinus opacification in the CT scans and cytokine expression was reduced in the laser-treated group, though without statistical significance. LLLT could be an effective option for the management of RS concerning radiological, histological, and molecular parameters.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference52 articles.
1. The International Study of the Allergic Rhinitis Survey: Outcomes from 4 geographical regions;Passali;Asia Pac. Allergy,2018
2. International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis;Wise;Int. Forum Allergy Rhinol.,2018
3. Human placental extract reduces allergic inflammation in a murine allergic rhinitis model;Kim;Laryngoscope,2014
4. Low-level laser therapy: A useful technique for enhancing the proliferation of various cultured cells;AlGhamdi;Lasers Med. Sci.,2012
5. Biological effects of low level laser therapy;Farivar;J. Lasers Med. Sci.,2014
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献