Abstract
Melanoma is a common and aggressive tumor originating from melanocytes. The increasing incidence of cutaneous melanoma in recent last decades highlights the need for predictive biomarkers studies. Melanoma development is a complex process, involving the interplay of genetic, epigenetic, and environmental factors. Genetic aberrations include BRAF, NRAS, NF1, MAP2K1/MAP2K2, KIT, GNAQ, GNA11, CDKN2A, TERT mutations, and translocations of kinases. Epigenetic alterations involve microRNAs, non-coding RNAs, histones modifications, and abnormal DNA methylations. Genetic aberrations and epigenetic marks are important as biomarkers for the diagnosis, prognosis, and prediction of disease recurrence, and for therapeutic targets. This review summarizes our current knowledge of the genomic and epigenetic changes in melanoma and discusses the latest scientific information.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference129 articles.
1. Melanocytes in Development and Cancer;Uong;J. Cell Physiol.,2010
2. Cutaneous Melanoma;Eggermont;Lancet,2014
3. Melanoma: Molecular Genetics, Metastasis, Targeted Therapies, Immunotherapies, and Therapeutic Resistance;Wagstaff;Genes Dis.,2022
4. Bolognia, J.L., Schaffer, J.V., and Cerroni, L. (2017). Dermatology, Elsevier Saunders. [4th ed.].
5. Acral Lentiginous Melanoma;Goydos;Cancer Treat. Res.,2016
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献