Identifying Protein Interactions with Viral DNA Genomes during Virus Infection-Reference-Cited by-同舟云学术

Identifying Protein Interactions with Viral DNA Genomes during Virus Infection

Published:2024-05-25 Issue:6 Volume:16 Page:845
ISSN:1999-4915
Container-title:Viruses
language:en
Short-container-title:Viruses

Author:

Packard Jessica E.¹^ORCID,Kumar Namrata²³,Weitzman Matthew D.²³^ORCID,Dembowski Jill A.¹^ORCID

Affiliation:

1. Department of Biological Sciences, School of Science and Engineering, Duquesne University, Pittsburgh, PA 15282, USA

2. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

3. Division of Protective Immunity, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA

Abstract

Viruses exploit the host cell machinery to enable infection and propagation. This review discusses the complex landscape of DNA virus–host interactions, focusing primarily on herpesviruses and adenoviruses, which replicate in the nucleus of infected cells, and vaccinia virus, which replicates in the cytoplasm. We discuss experimental approaches used to discover and validate interactions of host proteins with viral genomes and how these interactions impact processes that occur during infection, including the host DNA damage response and viral genome replication, repair, and transcription. We highlight the current state of knowledge regarding virus–host protein interactions and also outline emerging areas and future directions for research.

Funder

National Institutes of Health

Penn Center for Genome Integrity

Publisher

MDPI AG

Link

https://www.mdpi.com/1999-4915/16/6/845/pdf

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