Comprehensive Review of Acute Pancreatitis Pain Syndrome

Author:

Beiriger Jacob1,Khan Adnan1,Yan Brian1,Ross Heather1,Wang Makala1,Carducci Michael1ORCID,Parra Natalia Salinas1ORCID,Chowdhury Salil1,Erwin Ryan1,Forrest Paul1,Chen Sarah1,Gerber Alexis1

Affiliation:

1. Department of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA

Abstract

Pancreatitis is a condition that causes inflammation in the pancreas, an organ located behind the stomach. This condition often presents as neuropathic, inflammatory, and/or visceral pain. Acute pancreatitis is typically characterized by sudden and severe abdominal pain, often in the upper right part of the abdomen. The pain from pancreatitis can be caused by different mechanisms, such as abnormal activation of pancreatic zymogens or NF-κB mediated inflammation in the pancreas. The treatment of pancreatitis depends on its type, severity, and underlying cause. Hospitalization and medications are typically necessary, while in others, surgery may be required. Proper management of pancreatitis is essential, as it can help reduce the risk of complications and improve the patient’s quality of life. The literature on pancreatitis pain management evaluates systematic approaches and the effectiveness of various treatments, such as lidocaine, opioid agonists, ketamine, magnesium, endoscopic methods, spinal cord stimulation, and other novel treatments present opportunities for exploration in pancreatitis pain management.

Publisher

MDPI AG

Subject

Gastroenterology,Oncology,Immunology and Microbiology (miscellaneous),Hepatology

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