Ileocolic Anastomosis Dehiscence in Colorectal Cancer Surgery

Author:

Gomes Sara Lima1,Santos Pedro Miguel Dias dos2ORCID,Costa Pereira Joaquim3,Martins Sandra F.456ORCID

Affiliation:

1. School of Medicine, University of Minho, 4710-057 Braga, Portugal

2. Torres Vedras’s Hospital, Internship in General Surgery at Braga’s Hospital, 2560-295 Torres Vedras, Portugal

3. Department of General Surgery at Braga’s Hospital, 4710-243 Braga, Portugal

4. Life and Health Science Research Institute (ICVS), School of Medicine, University of Minho, 4710-057, Braga, Portugal

5. Life and Health Sciences Research Institute (ICVS)/3B’s-PT Government Associate Laboratory, 4806-909 Guimarães, Portugal

6. Coloproctology Unit, Braga’s Hospital, 4710-243 Braga, Portugal

Abstract

Background: Anastomotic leakage (AL) is one of the most feared complications in colorectal cancer (CRC) surgery. Although many series have reported the general risk factors for AL, published studies focusing on ileocolic anastomosis are scarce. The main aim of this study was to identify potential risk factors associated with ileocolic anastomosis dehiscence in surgery for CRC. Methods: A total of 188 patients who underwent primary ileocolic anastomosis after elective CRC surgery in Braga’s Hospital from November of 2018 to February of 2022 were included. A multivariate logistic regression analysis was carried out to identify independent risk factors for AL. Results: AL occurred in 13 patients (6.9%), and about three-fourths of these patients required surgical re-intervention. The mortality rate was 5.3%. Diabetes mellitus, ASA score of ≥3, laparotomy or conversion to laparotomy approach, postoperative blood transfusion, and postoperative hypoalbuminemia were associated with an increased risk of AL. In the multivariable analysis, postoperative hypoalbuminemia (p = 0.018; OR: 0.281; CI: 0.098; 0.806) and shorter operating time (p = 0.038; OR: 0.985; CI: 0.972; 0.999) were independent risk factors for AL. Conclusions: Postoperative hypoalbuminemia and shorter operating time are independent risk factors for AL after ileocolic anastomosis.

Publisher

MDPI AG

Subject

Gastroenterology,Oncology,Immunology and Microbiology (miscellaneous),Hepatology

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