Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes

Author:

Chiu Daniel1,Rhee John1,Gonzalez Castro L. Nicolas2ORCID

Affiliation:

1. Department of Neuro-Oncology, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA

2. Center for Neuro-Oncology, Dana-Farber Cancer Institute, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA

Abstract

Paraneoplastic antibody syndromes result from the anti-tumor antibody response against normal antigens ectopically expressed by tumor cells. Although this antibody response plays an important role in helping clear a nascent or established tumor, the engagement of antigens expressed in healthy tissues can lead to complex clinical syndromes with challenging diagnosis and management. The majority of known paraneoplastic antibody syndromes have been found to affect the central and peripheral nervous system. The present review provides an update on the pathophysiology of paraneoplastic neurologic syndromes, as well as recommendations for their diagnosis and treatment.

Publisher

MDPI AG

Subject

Drug Discovery,Immunology,Immunology and Allergy

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