Differential Immunostimulatory Effects of Lipoteichoic Acids Isolated from Four Strains of Lactiplantibacillus plantarum

Abstract

The intestinal health and immune modulatory effects of probiotics are well known. As with live bacteria, several studies demonstrating the ability of dead cells to improve gut health and immunity have suggested varying potentials for microbes to affect the human gut. The effect of dead microbes most likely derives from the cell wall of the microorganism. In this study, the functionality of lipoteichoic acid (LTA), a cell wall component, isolated from four stains of Lactiplantibacillus plantarum, K8, K88, K5-5, and K55-5, and the relationship between LTAs and their receptors were investigated. The four strains of L. plantarum have different LTA structures, which contributed to different immune activities in the immune cells. We confirmed that the different binding abilities with the host cell surface receptors, along with the differences in signal pathway, were due to the structural differences of the LTAs. LTA is an important postbiotic that induces various immunomodulatory actions.