The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota-Reference-Cited by-同舟云学术

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

Published:2024-05-24 Issue:11 Volume:13 Page:1633
ISSN:2304-8158
Container-title:Foods
language:en
Short-container-title:Foods

Author:

Yuan Jingjing¹²³^ORCID,Hu Yueyun¹⁴,Yang Dongmei¹,Zhou An¹³^ORCID,Luo Shengyong⁵,Xu Na⁶,Dong Jiaxing¹,He Qing¹,Zhang Chenxu¹,Zhang Xinyu¹,Ji Zhangxin¹,Li Qinglin¹^ORCID,Chu Jun²⁷^ORCID

Affiliation:

1. Key Laboratory of Xin’an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei 230012, China

2. Research and Technology Center, Anhui University of Chinese Medicine, Hefei 230012, China

3. Functional Activity and Resource Utilization on Edible and Medicinal Fungi Joint Laboratory of Anhui Province, Anhui University of Chinese Medicine, Hefei 230012, China

4. Affiliated Hospital of Yangzhou University, Yangzhou 225012, China

5. Anhui Academy of Medical Sciences, Hefei 230061, China

6. State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science and International Joint Laboratory on Tea Chemistry and Health Effects of Ministry of Education, Anhui Agricultural University, Hefei 230036, China

7. Institute of Surgery, Anhui Academy of Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230012, China

Abstract

Obesity is a multifactorial chronic metabolic disease with multiple complications. Crataegus pinnatifida (CP) and Wolfiporia extensa (WE) are traditional functional foods with improving metabolic health properties. This study demonstrated the effect of CP and WE combination on ameliorating obesity induced by a high-fat diet (HFD). Moreover, the CP-WE food pair ameliorated HFD-induced metabolic disorders, including glucose intolerance, insulin resistance, hyperlipidemia, and hepatic steatosis. 16S rRNA gene amplicon sequencing and analysis revealed that CP combined with WE reshaped the composition of gut microbiota in HFD-fed mice. Furthermore, correlation analysis revealed a substantial association between the obesity-related parameters and the shifts in predominant bacterial genera influenced by the food pair intervention. In conclusion, this study demonstrated that the CP-WE food pair ameliorated HFD-induced obesity and reshaped gut microbiota composition, providing a promising approach to combat obesity through specific food combinations.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Anhui Provincial Education Department

Natural Science Foundation of Anhui University of Chinese Medicine

National Key Laboratory of Cotton Bio-breeding and Integrated Utilization Open Fund

Research Funds of Joint Research Center for Food Nutrition and Health of IHM

Publisher

MDPI AG

Link

https://www.mdpi.com/2304-8158/13/11/1633/pdf

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