New Biodegradable Copolymers Based on Betulin and Hydroxycarboxylic Acid Derivatives

Author:

Zinovyev Alexey1,Gorbunova Alina1ORCID,Chernova Anna2,Carabineiro Sónia A. C.3ORCID,Poletykina Ekaterina1,Bugaeva Anastasia2,Novikov Viktor1,Kolobova Ekaterina1ORCID,Pestryakov Alexey1ORCID

Affiliation:

1. Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, Lenin Av. 30, 634050 Tomsk, Russia

2. School of Earth Sciences and Engineering, National Research Tomsk Polytechnic University, Lenin Av. 30, 634050 Tomsk, Russia

3. LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal

Abstract

In this study, we propose an approach to the synthesis of new biodegradable polymer materials based on renewable raw feedstock (betulin) and derivatives of hydroxycarboxylic acids using a catalyst/catalytic system (γ-Al2O3, γ-Al2O3/TBHP) that is safe for health and the environment. The resulting polymers are linear thermoplastic polymers that undergo collapse upon melting in the presence of atmospheric oxygen. Moreover, these polymers demonstrate non-toxicity towards a range of Gram-positive and Gram-negative bacteria. The polycondensation of betulin with butyl lactate is particularly noteworthy.

Funder

Ministry of Education and Science of the Russian Federation Program

FCT/MCTES (Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior

Scientific Employment Stimulus—Institutional Call

Publisher

MDPI AG

Reference23 articles.

1. Betulin and Its Derivatives. Chemistry and Biological Activity;Tolstikov;Chem. Sustain. Dev.,2005

2. Recent Developments on the Synthesis and Applications of Betulin and Betulinic Acid Derivatives as Therapeutic Agents;Jonnalagadda;Studies in Natural Products Chemistry,2017

3. Birch Bark Extractives: Isolation, Composition, Properties, Application;Kislitsyn;Chem. Wood,1994

4. Niewolik, D., Bednarczyk-Cwynar, B., Ruszkowski, P., Sosnowski, T.R., and Jaszcz, K. (2021). Bioactive Betulin and Peg Based Polyanhydrides for Use in Drug Delivery Systems. Int. J. Mol. Sci., 22.

5. Glycopolymers Bearing Galactose and Betulin: Synthesis, Encapsulation, and Lectin Recognition;Ma;Biomacromolecules,2017

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3