Bioactive Oxylipins Profile in Marine Microalgae
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Published:2023-02-22
Issue:3
Volume:21
Page:136
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ISSN:1660-3397
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Container-title:Marine Drugs
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language:en
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Short-container-title:Marine Drugs
Author:
Linares-Maurizi Amandyne12, Reversat Guillaume1, Awad Rana1, Bultel-Poncé Valérie1, Oger Camille1ORCID, Galano Jean-Marie1, Balas Laurence1ORCID, Durbec Anaelle3, Bertrand-Michel Justine3ORCID, Durand Thierry1, Pradelles Rémi2, Vigor Claire1ORCID
Affiliation:
1. Institut des Biomolécules Max Mousseron, IBMM, Université de Montpellier, CNRS, ENSCM, 34093 Montpellier, France 2. Microphyt, 713 Route de Mudaison, 34670 Baillargues, France 3. MetaToul, MetaboHUB, Inserm/UPS UMR 1048, I2MC, Institut des Maladies Métaboliques et Cardiovasculaires, 31077 Toulouse, France
Abstract
Microalgae are photosynthetic microscopic organisms that serve as the primary food source in aquatic environments. Microalgae can synthesize a wide variety of molecules, such as polyunsaturated fatty acids (PUFAs) of the omega-3 and omega-6 series. Oxidative degradation of PUFA due to radical and/or enzymatic conversion leads to the formation of oxylipins, which are compounds known for their bioactive properties. In the present study, we aim to profile oxylipins from five microalgae species grown in 10-L photo-bioreactors under optimal conditions. During their exponential phase, microalgae were harvested, extracted and analyzed by LC-MS/MS to determine the qualitative and quantitative profile of oxylipins for each species. The five different selected microalgae revealed a high diversity of metabolites, up to 33 non-enzymatic and 24 enzymatic oxylipins present in different concentrations. Taken together, these findings highlight an interesting role of marine microalgae as a source of bioactive lipids mediators, which we hypothesize have an important function in preventive health measures such as amelioration of inflammation. The rich mixture of oxylipins may display advantages to biological organisms, especially by providing for human health benefits including antioxidant, anti-inflammatory, neuroprotective or immunomodulator activities. Some oxylipins are also well known for their cardiovascular properties.
Funder
Association Nationale de la Recherche et de la Technologie
Subject
Drug Discovery,Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Pharmaceutical Science
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