Affiliation:
1. Department of Biomedical and Neuromotor Sciences, University of Bologna, 40123 Bologna, Italy
2. Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy
3. Istituto di Ricovero a Carattere Scientifico Istituto Delle Scienze Neurologiche di Bologna (ISNB), 40139 Bologna, Italy
Abstract
Narcolepsy is a chronic central disorder of hypersomnolence most frequently arising during childhood/adolescence. This review article examined the literature concerning the etiology, prevalence, clinical course, and treatment of children with type 1 narcolepsy (NT1). Core symptoms of pediatric NT1 include excessive daytime sleepiness (EDS) and cataplexy, together with disrupted night sleep, sleep paralysis, and hypnagogic and hypnopompic hallucinations that can also occur. This disease frequently presents several comorbidities, such as obesity and precocious puberty, conditions ranging from psychological distress to psychiatric disorders, and cognitive aspects that further worsen the clinical picture. NT1 impairs the quality of life of children, thus calling for an early diagnosis and adequate treatment. To date, pharmacological treatments have been registered for childhood NT1 and can improve symptoms. Non-pharmacological approaches are also essential to improve patients’ well-being, ranging from behavioral treatments (e.g., planned napping) to psychosocial interventions (e.g., school programs). Multidisciplinary treatment management and early diagnosis are key factors in order to allow for adequate quality of life and development in children with NT1.
Reference170 articles.
1. American Academy of Sleep Medicine (2023, August 15). International Classification of Sleep Disorders, Available online: https://aasm.org/clinical-resources/international-classification-sleep-disorders/.
2. Narcolepsy as an autoimmune disease: The role of H1N1 infection and vaccination;Partinen;Lancet Neurol.,2014
3. Changed epidemiology of narcolepsy before, during and after the 2009 H1N1 pandemic: A nationwide narcolepsy surveillance network study in mainland China, 1990–2017;Wang;Sleep,2023
4. New 2013 incidence peak in childhood narcolepsy: More than vaccination?;Zhang;Sleep,2021
5. Narcolepsy in childhood;Nevsimalova;Sleep Med. Rev.,2009