Secondary Metabolites of Fomitopsis betulina: Chemical Structures, Biological Activity and Application Prospects

Author:

Li Jianghao1,Li Ziheng1,Duan Yingce1,Liu Chengwei1ORCID,Yan Meixia2

Affiliation:

1. Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang, College of Life Science, Northeast Forestry University, Harbin 150040, China

2. Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China

Abstract

Fomitopsis betulina, as a macrofungus with both medicinal and dietary applications, is renowned for its rich content of bioactive substances. The recent advancements in research have significantly enhanced our understanding of its polysaccharides, cellulose-degrading enzymes, and wide range of secondary metabolites. This paper provides a comprehensive review of the artificial cultivation techniques and the chemical profiling of over 100 secondary metabolites identified in F. betulina, including terpenoids, phenols, and various other classes. These compounds exhibit notable pharmacological activities, such as anti-cancer, anti-inflammatory, antimicrobial, antiviral, and anti-malarial effects. Moreover, this review delves into the genomic analysis of F. betulina, focusing on the prediction and classification of terpene synthases, which play a crucial role in the biosynthesis of these bioactive compounds. This insight is instrumental for potentially facilitating future biochemical studies and pharmaceutical applications. Through this review, we aim to solidify the foundation for future in-depth studies and the development of new drugs derived from this promising natural resource.

Funder

Fundamental Research Funds for the Central Universities

Natural Science Foundation of Heilongjiang Province of China

Agricultural Science and Technology Innovation Program

Publisher

MDPI AG

Reference71 articles.

1. Chemodiversity, pharmacological activity, and biosynthesis of specialized metabolites from medicinal model fungi Ganoderma lucidum;Du;Chin. Med.,2024

2. The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium: A review;Qi;Chin. J. Nat. Med.,2024

3. A comprehensive review of secondary metabolites from the genus Agrocybe: Biological activities and pharmacological implications;Zhang;Mycology,2024

4. Bioactive components of Laetiporus species and their pharmacological effects;Duan;Appl. Microbiol. Biotechnol.,2022

5. The pharmacological potential of mushrooms;Lindequist;Evid. Based Complement. Altern. Med.,2005

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