Asperinsuterpenes A–C from the Fungus Aspergillus insuetus BTBU20220155

Author:

Zhang Xinjun1,Song Fuhang2ORCID,Han Jiahui3,Wang Long4,Ma Linlin5,Xu Xiuli3

Affiliation:

1. Key Laboratory of Forest Ecology in Tibet Plateau (Ministry of Education), Institute of Tibet Plateau Ecology, Tibet Agriculture & Animal Husbandry University, Nyingchi 860000, China

2. Key Laboratory of Geriatric Nutrition and Health, Ministry of Education of China, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, China

3. Key Laboratory of Polar Geology and Marine Mineral Resources, Ministry of Education, School of Ocean Sciences, China University of Geosciences, Beijing 100083, China

4. State Key Lab of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

5. Institute for Biomedicine and Glycomics, School of Environment and Science, Griffith University, Brisbane, QLD 4111, Australia

Abstract

Three new meroterpenoids, asperinsuterpenes A–C (1–3), and eight previously reported natural products, namely asnovolin I (4), (2′E,4′E,6′E)-6-(1′-carboxyocta-2′,4′,6′-triene)-9-hydroxydrim-7-ene-11,12-olide (5), (2′E,4′E,6′E)-6-(1′-carboxyocta-2′,4′,6′-triene)-11,12-epoxy-9,11-dihydroxydrim-7-ene (6), cinereain (7), carnequinazolines A and B (8 and 9), carnemycin B (10), and stromemycin (11) were isolated from the fungus Aspergillus insuetus, strain BTBU20220155. The structures of the compounds were determined based on spectroscopic techniques, including 1D and 2D NMR, HRESIMS, and ECD experiments. The in vitro antimicrobial evaluation revealed that compounds 5 and 11 exhibited inhibitory activity against Candida albicans, with minimum inhibitory concentration (MIC) values of 12.5 and 25 μg/mL, respectively. These findings suggest that A. insuetus is a promising source of bioactive natural products with potential applications in antifungal therapy.

Funder

Guangxi Key Laboratory of Beibu Gulf Marine Resources, Environment and Sustainable Development

Publisher

MDPI AG

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