Focal Pulsed Field Ablation for Atrial Arrhythmias: Efficacy and Safety under Deep Sedation

Author:

Weyand Sebastian1ORCID,Adam Viola1,Biehler Paloma1,Hägele Patricia1,Hanger Simon1,Heinzmann David2,Löbig Stephanie1,Pinchuk Andrei1,Waechter Christian3,Seizer Peter1

Affiliation:

1. Department of Cardiology, Ostalb Clinic Aalen, Im Kaelblesrain 1, 73430 Aalen, Germany

2. Department of Cardiology, University Hospital Tuebingen, Otfried-Mueller-Straße 10, 72076 Tuebingen, Germany

3. Department of Cardiology, University Hospital Marburg, Philipps University Marburg, Baldingerstraße, 35043 Marburg, Germany

Abstract

Focal pulsed field ablation (PFA) is a novel technique for treating cardiac arrhythmias. It has demonstrated positive results in initial studies and has a good safety profile. In recent studies, PFA was often utilized for first-time pulmonary vein isolation (PVI) and was performed under general anesthesia. In our study, we assessed the feasibility, safety, acute procedural efficacy, and efficiency of focal PFA under deep sedation in patients, 80% of whom had undergone at least one left atrial ablation previously. We treated 30 patients (71 ± 7, 46% male) using the CENTAURI system for various atrial arrhythmias, including atrial fibrillation, typical and atypical atrial flutter, and focal atrial tachycardia. The average procedure and fluoroscopy times were 122 ± 43 min and 9 ± 7 min, respectively. A total of 83.33% of patients received additional line ablations beyond PVI, specifically targeting the posterior box and anterior mitral line. All ablations were successfully performed in deep sedation with only one major and one minor complication observed. The major complication was a vasospasm of the right coronary artery during ablation of the cavotricuspid isthmus, which was treated successfully with intracoronary nitroglycerin. All patients could be discharged in sinus rhythm. Moreover, adenosine appears effective in identifying dormant conduction in some patients after focal PFA. In conclusion, focal PFA is an effective approach for complex left atrial ablations under deep sedation, offering both high efficacy and efficiency with a reliable safety profile. Studies on long-term outcomes are needed.

Publisher

MDPI AG

Subject

General Medicine

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