Emericellopsis maritima and Purpureocillium lilacinum Marine Fungi as a Source of Functional Fractions with Antioxidant and Antitumor Potential in Colorectal Cancer: A Preliminary Study
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Published:2023-10-20
Issue:10
Volume:11
Page:2024
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ISSN:2077-1312
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Container-title:Journal of Marine Science and Engineering
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language:en
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Short-container-title:JMSE
Author:
Perazzoli Gloria123, de los Reyes Carolina4, Pinedo-Rivilla Cristina4ORCID, Durán-Patrón Rosa4ORCID, Aleu Josefina4ORCID, Cabeza Laura123, Melguizo Consolación123ORCID, Prados Jose123ORCID
Affiliation:
1. Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), 18100 Granada, Spain 2. Department of Anatomy and Embryology, University of Granada, 18071 Granada, Spain 3. Instituto de Investigación Biosanitaria de Granada, (ibs.GRANADA), 18014 Granada, Spain 4. Organic Chemistry Department, Faculty of Sciences, University of Cádiz, 11510 Puerto Real, Spain
Abstract
The marine environment is a promising source of natural products with possible pharmacological applications. In this sense, marine microorganisms, especially marine fungi, can produce bioactive compounds with various therapeutic properties. Colorectal cancer (CRC) represents a major health problem worldwide, since the treatments used to date are not capable of improving patient survival; that is why natural compounds from marine fungi offer a promising alternative. This study focused on evaluating the antitumor and antioxidant activity of fractions derived from the marine fungi E. maritima and P. lilacinum in two CRC cell lines T84 and SW480. Fractions Fr-EM6, Fr-EM7, Fr-EM8 and Fr-PLMOH-3 demonstrated potent cytotoxic activity in tested CRC cell lines with no activity in the non-tumor line. In particular, the Fr-PLMOH-3 fraction from P. lilacinum showed significant antiproliferative effects on T84 and SW480 cell lines and exhibited a greater cytotoxic effect on cancer stem cells compared to tumor cells. Furthermore, the Fr-EM8 fraction from E. maritima demonstrated a strong antioxidant capacity. These findings highlight the potential of compounds of marine origin as effective and selective antitumor agents for the treatment of CRC. Further studies are needed to explore the underlying mechanisms and potential clinical applications of these bioactive fractions and compounds.
Funder
Regional Government of Andalusia International Campus of Excellence in Marine Science
Subject
Ocean Engineering,Water Science and Technology,Civil and Structural Engineering
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