The Complex Role of the Microbiome in Non-Small Cell Lung Cancer Development and Progression

Author:

Souza Vanessa G. P.12ORCID,Forder Aisling1,Pewarchuk Michelle E.1,Telkar Nikita13ORCID,de Araujo Rachel Paes2ORCID,Stewart Greg L.1,Vieira Juliana1,Reis Patricia P.24ORCID,Lam Wan L.1

Affiliation:

1. British Columbia Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada

2. Molecular Oncology Laboratory, Experimental Research Unit, School of Medicine, São Paulo State University (UNESP), Botucatu 18618-687, SP, Brazil

3. British Columbia Children’s Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada

4. Department of Surgery and Orthopedics, Faculty of Medicine, São Paulo State University (UNESP), Botucatu 18618-687, SP, Brazil

Abstract

In recent years, there has been a growing interest in the relationship between microorganisms in the surrounding environment and cancer cells. While the tumor microenvironment predominantly comprises cancer cells, stromal cells, and immune cells, emerging research highlights the significant contributions of microbial cells to tumor development and progression. Although the impact of the gut microbiome on treatment response in lung cancer is well established, recent investigations indicate complex roles of lung microbiota in lung cancer. This article focuses on recent findings on the human lung microbiome and its impacts in cancer development and progression. We delve into the characteristics of the lung microbiome and its influence on lung cancer development. Additionally, we explore the characteristics of the intratumoral microbiome, the metabolic interactions between lung tumor cells, and how microorganism-produced metabolites can contribute to cancer progression. Furthermore, we provide a comprehensive review of the current literature on the lung microbiome and its implications for the metastatic potential of tumor cells. Additionally, this review discusses the potential for therapeutic modulation of the microbiome to establish lung cancer prevention strategies and optimize lung cancer treatment.

Funder

Canadian Institutes of Health Research

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior/Coordination

Publisher

MDPI AG

Subject

General Medicine

Reference187 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Sung;CA Cancer J. Clin.,2021

2. The Biology and Management of Non-Small Cell Lung Cancer;Herbst;Nature,2018

3. The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer;Goldstraw;J. Thorac. Oncol. Off. Publ. Int. Assoc. Study Lung Cancer,2016

4. Estimates and Projections of the Global Economic Cost of 29 Cancers in 204 Countries and Territories From 2020 to 2050;Chen;JAMA Oncol.,2023

5. Lung Cancer: Biology and Treatment Options;Hassan;Biochim. Biophys. Acta,2015

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3