Abstinence Restores Cardiac Function in Mice with Established Alcohol-Induced Cardiomyopathy

Author:

Edavettal Joshua M.1,Harris Nicholas R.1,Cohen Sarah E.1,Paloczi Janos1ORCID,Chandrasekar Bysani23,Gardner Jason D.1

Affiliation:

1. Department of Physiology, LSU Health Sciences Center—New Orleans, New Orleans, LA 70112, USA

2. Department of Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA

3. Department of Medical Pharmacology and Physiology, Dalton Cardiovascular Research Center, and Harry S. Truman Memorial Veterans Hospital, Columbia, MO 65212, USA

Abstract

Alcohol-induced cardiomyopathy (ACM) has a poor prognosis with up to a 50% chance of death within four years of diagnosis. There are limited studies investigating the potential of abstinence for promoting repair after alcohol-induced cardiac damage, particularly in a controlled preclinical study design. Here, we developed an exposure protocol that led to significant decreases in cardiac function in C57BL6/J mice within 30 days; dP/dt max decreased in the mice fed alcohol for 30 days (8054 ± 664.5 mmHg/s compared to control mice: 11,188 ± 724.2 mmHg/s, p < 0.01), and the dP/dt min decreased, as well (−7711 ± 561 mmHg/s compared to control mice: −10,147 ± 448.2 mmHg/s, p < 0.01). Quantitative PCR was used to investigate inflammatory and fibrotic biomarkers, while histology was used to depict overt changes in cardiac fibrosis. We observed a complete recovery of function after abstinence (dP/dt max increased from 8054 ± 664 mmHg/s at 30 days to 11,967 ± 449 mmHg/s after abstinence, p < 0.01); further, both inflammatory and fibrotic biomarkers decreased after abstinence. These results lay the groundwork for future investigation of the molecular mechanisms underlying recovery from alcohol-induced damage in the heart.

Funder

National Institute on Alcohol Abuse and Alcoholism

Veterans Affairs

Publisher

MDPI AG

Subject

General Medicine

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