Affiliation:
1. Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200090, China
2. Neurosurgical Institute, Fudan University, Shanghai 200032, China
Abstract
Many vascular diseases are linked to lipid metabolism disorders, which cause lipid accumulation and peroxidation in the vascular wall. These processes lead to degenerative changes in the vessel, such as phenotypic transformation of smooth muscle cells and dysfunction and apoptosis of endothelial cells. In intracranial aneurysms, the coexistence of lipid plaques is often observed, indicating localized lipid metabolism disorders. These disorders may impair the function of the vascular wall or result from it. We summarize the literature on the relationship between lipid metabolism disorders and intracranial aneurysms below.
Funder
National Natural Science Foundation of China
Shanghai Excellent Academic Leader Program
Clinical Research Plan of SHDC
Shanghai Science and Technology Commission Project
Shanghai Sailing Program
Shanghai Municipal Science and Technology Major Project
Zhang Jiang Laboratory
CAMS Innovation Fund for Medical Sciences
Subject
Molecular Biology,Biochemistry