MicroRNA (miR)-124: A Promising Therapeutic Gateway for Oncology-Reference-Cited by-同舟云学术

MicroRNA (miR)-124: A Promising Therapeutic Gateway for Oncology

Published:2023-06-28 Issue:7 Volume:12 Page:922
ISSN:2079-7737
Container-title:Biology
language:en
Short-container-title:Biology

Author:

Gourishetti Karthik¹²^ORCID,Balaji Easwaran Vignesh³^ORCID,Mostakim Youssef¹²⁴,Ranganath Pai K. Sreedhara³^ORCID,Bhere Deepak¹²^ORCID

Affiliation:

1. Biotherapeutics Laboratory, School of Medicine Columbia, University of South Carolina, Columbia, SC 29209, USA

2. Department of Pathology, Microbiology, and Immunology, School of Medicine Columbia, University of South Carolina, Columbia, SC 29209, USA

3. Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India

4. College of Arts and Sciences, University of South Carolina, Columbia, SC 29208, USA

Abstract

MicroRNA (miR) are a class of small non-coding RNA that are involved in post-transcriptional gene regulation. Altered expression of miR has been associated with several pathological conditions. MicroRNA-124 (miR-124) is an abundantly expressed miR in the brain as well as the thymus, lymph nodes, bone marrow, and peripheral blood mono-nuclear cells. It plays a key role in the regulation of the host immune system. Emerging studies show that dysregulated expression of miR-124 is a hallmark in several cancer types and it has been attributed to the progression of these malignancies. In this review, we present a comprehensive summary of the role of miR-124 as a promising therapeutic gateway in oncology.

Funder

the National Institutes of Health—National Cancer Institute

Publisher

MDPI AG

Subject

General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology

Link

https://www.mdpi.com/2079-7737/12/7/922/pdf

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