The Role of Autophagy in the Female Reproduction System: For Beginners to Experts in This Field
Author:
Nakashima Akitoshi1, Furuta Atsushi1, Yamada Kiyotaka1, Yoshida-Kawaguchi Mihoko1, Yamaki-Ushijima Akemi1, Yasuda Ippei1, Ito Masami1, Yamashita Satoshi1, Tsuda Sayaka1, Yoneda Satoshi1, Cheng Shibin2, Sharma Surendra2ORCID, Shima Tomoko1
Affiliation:
1. Department of Obstetrics and Gynecology, Toyama Autophagy Team in Gynecology and Obstetrics, University of Toyama, Toyama 930-0194, Japan 2. Departments of Pediatrics, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI 02905, USA
Abstract
Autophagy is a fundamental process involved in regulating cellular homeostasis. Autophagy has been classically discovered as a cellular process that degrades cytoplasmic components non-selectively to produce energy. Over the past few decades, this process has been shown to work in energy production, as well as in the reduction of excessive proteins, damaged organelles, and membrane trafficking. It contributes to many human diseases, such as neurodegenerative diseases, carcinogenesis, diabetes mellitus, development, longevity, and reproduction. In this review, we provide important information for interpreting results related to autophagic experiments and present the role of autophagy in this field.
Funder
MHLW Research on Risk of Chemical Substances Program Tamura Science and Technology Foundation, Toyama Prefecture Medical Association JST Moonshot R&D JSPS KAKENHI
Subject
General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology
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