Affiliation:
1. Spinal Cord Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada
Abstract
Tau, a member of the microtubule-associated proteins, is a known component of the neuronal cytoskeleton; however, in the brain tissue, it is involved in other vital functions beyond maintaining the cellular architecture. The pathologic tau forms aggregates inside the neurons and ultimately forms the neurofibrillary tangles. Intracellular and extracellular accumulation of different tau isoforms, including dimers, oligomers, paired helical filaments and tangles, lead to a highly heterogenous group of diseases named “Tauopathies”. About twenty-six different types of tauopathy diseases have been identified that have different clinical phenotypes or pathophysiological characteristics. Although all these diseases are identified by tau aggregation, they are distinguishable based on the specific tau isoforms, the affected cell types and the brain regions. The neuropathological and phenotypical heterogeneity of these diseases impose significant challenges for discovering new diagnostic and therapeutic strategies. Here, we review the recent literature on tau protein and the pathophysiological mechanisms of tauopathies. This article mainly focuses on physiologic and pathologic tau and aims to summarize the upstream and downstream events and discuss the current diagnostic approaches and therapeutic strategies.
Funder
University of Manitoba Graduate Studentship Fund
GETS
Natural Sciences and Engineering Research Council of Canada
Subject
General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology
Reference118 articles.
1. Current Directions in Tau Research: Highlights from Tau 2020;Sexton;Alzheimer’s Dement.,2021
2. Gallo, D., Ruiz, A., and Sánchez-Juan, P. (Neuroscience, 2022). Genetic Architecture of Primary Tauopathies, Neuroscience, in press.
3. The First NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy;McKee;Acta Neuropathol.,2016
4. WHO (2022, August 27). Dementia. Available online: https://www.who.int/health-topics/dementia#tab=tab_2.
5. Distribution of Five Clinically Important Neuroglial Proteins in the Human Brain;Kultima;Mol. Brain,2022
Cited by
11 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献