Non-Small Cell Lung Cancer Harboring Concurrent EGFR Genomic Alterations: A Systematic Review and Critical Appraisal of the Double Dilemma

Author:

Gristina Valerio,La Mantia MariaORCID,Galvano Antonio,Cutaia Sofia,Barraco Nadia,Castiglia MartaORCID,Perez Alessandro,Bono MarcoORCID,Iacono Federica,Greco Martina,Calcara Katia,Calò Valentina,Rizzo Sergio,Incorvaia LorenaORCID,Lisanti Maria Chiara,Santanelli Giulia,Sardo Delia,Inguglia Sara,Insalaco Lavinia,Castellana Luisa,Cusenza Stefania,Pantuso Gianni,Russo Antonio,Bazan Viviana

Abstract

The molecular pathways which promote lung cancer cell features have been broadly explored, leading to significant improvement in prognostic and diagnostic strategies. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have dramatically altered the treatment approach for patients with metastatic non-small cell lung cancer (NSCLC). Latest investigations by using next-generation sequencing (NGS) have shown that other oncogenic driver mutations, believed mutually exclusive for decades, could coexist in EGFR-mutated NSCLC patients. However, the exact clinical and pathological role of concomitant genomic aberrations needs to be investigated. In this systematic review, we aimed to summarize the recent data on the oncogenic role of concurrent genomic alterations, by specifically evaluating the characteristics, the pathological significance, and their potential impact on the treatment approach.

Publisher

MDPI AG

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