Abstract
Evolutionary conservation is a measure of gene functionality that is widely used to prioritise long noncoding RNAs (lncRNA) in cancer research. Intriguingly, while updating our Cancer LncRNA Census (CLC), we observed an inverse relationship between year of discovery and evolutionary conservation. This observation is specific to cancer over other diseases, implying a sampling bias in the selection of lncRNA candidates and casting doubt on the value of evolutionary metrics for the prioritisation of cancer-related lncRNAs.
Funder
the Swiss National Science Foundation through the National Centre of Competence in Research (NCCR) “RNA & Disease”
The elements of long noncoding RNA function
Regenerative strategies for heart disease via targeting the long noncoding transcriptome
SNF Doc.mobility project
the Helmut Horten Stiftung, Swiss Cancer Research Foundation
the Werner and Hedy Berger Janser—Foundation for cancer research
Science Foundation Ireland through Future Research Leaders award
the NIH
Subject
Genetics,Molecular Biology,Biochemistry
Cited by
3 articles.
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