Serum Cobalt Concentration and DNA Methylation Signatures in Women with Obesity-Reference-Cited by-同舟云学术

Serum Cobalt Concentration and DNA Methylation Signatures in Women with Obesity

Published:2024-04-27 Issue:2 Volume:4 Page:85-92
ISSN:2673-4168
Container-title:Obesities
language:en
Short-container-title:Obesities

Author:

Noronha Natália Yumi¹²,Diani Luísa Maria¹,Rodrigues Guilherme da Silva¹^ORCID,Noma Isabela Harumi Yonehara³,Pereira Vanessa Aparecida Batista⁴^ORCID,Pinhel Marcela Augusta de Souza¹⁵^ORCID,Watanabe Lígia Moriguchi⁴⁶^ORCID,Morais Déborah Araújo⁷^ORCID,Barbosa Fernando⁷^ORCID,Nonino Carla Barbosa¹⁴

Affiliation:

1. Department of Internal Medicine, Ribeirão Preto Medical School, Ribeirão Preto 14040-907, SP, Brazil

2. Department of Gynecology and Obstetrics, University Medical Center Groningen, The University of Groningen, 9713 GZ Groningen, The Netherlands

3. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-220, SP, Brazil

4. Department of Health Sciences, Ribeirão Preto Medical School, Ribeirão Preto 14040-907, SP, Brazil

5. Department of Molecular Biology, São José do Rio Preto Medical School, São José do Rio Preto 15090-000, SP, Brazil

6. Department of Statistics and Operational Research, Faculty of Sciences of the University of Lisbon, 1649-004 Lisboa, Portugal

7. Department of Clinical, Bromatological and Toxicological Analysis, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo 14040-907, SP, Brazil

Abstract

Obesity, a multifactorial disorder, has been associated with alterations in metal metabolismand epigenetic modifications. This pilot case–control study aimed to investigate serum cobalt concentrations and associated DNA methylation patterns in women with obesity. Serum cobalt levels were measured using inductively coupled plasma mass spectrometry (ICP-MS), revealing significantly higher cobalt concentrations in participants with normal weight than in participants with obesity. Additionally, DNA methylation analysis identified differentially methylated positions (DMPs) associated with cobalt exposure, and DMPs between groups highlighted hypomethylation in the top DMPs in individuals with obesity. Functional enrichment analysis of these DMPs unveiled potential pathways implicated in apoptosis, cancer, and metabolic signaling, warranting further investigation into the mechanistic links. This study provides preliminary insights into the interplay between cobalt exposure, DNA methylation, and potential implications for obesity management.

Funder

São Paulo Research Foundation

National Council for Scientific and Technological Development

FAPESP

Academic Excellence Program from Coordination for Higher Education Staff Development

Publisher

MDPI AG

Link

https://www.mdpi.com/2673-4168/4/2/9/pdf

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