Innovative Strategies for Photoallergy Assessment: Breaking Free from Animal Models in Cosmetic Ingredient Development

Abstract

Photoallergy, a unique form of skin sensitization induced by specific compounds under ultraviolet irradiation, has traditionally been investigated using animals. However, the prohibition of animal testing for the assessment of cosmetic ingredients in Europe and other countries underscores the necessity for in vitro or in silico alternative methods. Currently, there are no validated methods for assessing photoallergy or photosensitization, presenting a significant challenge in the development of new cosmetic ingredients. This review examines the landscape of alternative methods for detecting photosensitization, emphasizing recent publications, and considering the underlying principles of the different proposed assays.