Effect of Phenolic Compounds Extracted from Turmeric (Curcuma longa L.) and Ginger (Zingiber officinale) on Cutaneous Wound Healing in Wistar Rats

Author:

Bouchama Chaymae12ORCID,Zinedine Abdellah3ORCID,Rocha João Miguel456ORCID,Chadli Noureddine1ORCID,El Ghadraoui Lahsen2,Chabir Rachida7,Raoui Sidi Mohammed8,Errachidi Faouzi2ORCID

Affiliation:

1. Immunology and Biodiversity Laboratory, Ain Chock Faculty of Sciences, Hassan II University, Casablanca 20100, Morocco

2. Functional Ecology and Environment Engineering Laboratory, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University (USMBA), Fez 30050, Morocco

3. BIOMARE Laboratory, Faculty of Sciences, Chouaib Doukkali University, EL Jadida 24000, Morocco

4. Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal

5. Laboratory for Process Engineering, Environment, Biotechnology and Energy (LEPABE), Faculty of Engineering, University of Porto (FEUP), Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal

6. Associate Laboratory in Chemical Engineering (ALiCE), Faculty of Engineering, University of Porto (FEUP), Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal

7. Laboratory of Human Pathology, Biomedicine and Environment, Team of Nutrition, Agri-Food and Environment, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University (USMBA), Fez 30050, Morocco

8. Higher Institute of Nursing Professions and Health Techniques, Fes annex of Meknes, Meknes 50000, Morocco

Abstract

Turmeric and ginger, widely used rhizomes in culinary arts, have several beneficial biological activities, such as hypoglycemic, hepato-protective, antimicrobial, and antioxidant properties. This work investigated the effects of three phenolic extracts isolated from turmeric and ginger rhizomes on anti-inflammatory and healing properties using the solid–liquid extraction method. Wistar rats were used as a biological model. The anti-inflammatory activity was evaluated on induced edema in the rat’s hind paw using carrageenan (1%). Paw volume was measured at 0 min, 45 min, 3 h, and 5 h. Treatment with turmeric and ginger extracts, administered at a dose of 100 mg/kg, revealed a reduction in edema volume by 98.8%, 94.8%, and 98.3% using an aqueous extract of turmeric, ethanolic extract of turmeric, and methanolic extract of ginger, respectively. The healing activity parameters of induced burns on the rat’s dorsal region in nine groups (7 rats each) were monitored daily throughout the experiment’s duration. Results showed that the application of creams composed of petroleum jelly dispersing turmeric and ginger extracts to wounds at a dose of 100 mg/kg g induced complete healing after 19 days while the negative control was only 60% cured. On day 14, the aqueous, ethanolic, and methanolic turmeric extracts nearly resulted in complete tissue repair by 95.26%, 98.34%, and 87.39%, respectively. According to the chromatographic analysis (Sephadex G50 column), there is a variation in the molecular weight distribution of phenolic compounds (polymers, oligomers, and monomers) in the three studied extracts, which has a differential effect on the anti-inflammatory and wound healing activities of the extracts.

Funder

USMBA University

Functional Ecology and Environment Engineering (FEEE) and Human Pathology, Biomedicine and Environment (HPBE) Laboratories

Publisher

MDPI AG

Subject

Dermatology,Pharmaceutical Science,Aging,Chemical Engineering (miscellaneous),Surgery

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