The Cosmeceutical Potential of the Yellow-Green Alga Trachydiscus minutus Aqueous Extract: Preparation of a Natural-Based Dermal Formula as a Proof of Concept
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Published:2023-05-10
Issue:3
Volume:10
Page:75
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ISSN:2079-9284
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Container-title:Cosmetics
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language:en
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Short-container-title:Cosmetics
Author:
Georgakis Nikolaos D.1ORCID, Ioannou Elisavet1ORCID, Chatzikonstantinou Marianna2, Merino Marián3, Chronopoulou Evangelia G.1ORCID, Mullor José Luis3, Madesis Panagiotis4ORCID, Labrou Nikolaos E.1ORCID
Affiliation:
1. Laboratory of Enzyme Technology, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos Street, GR-11855 Athens, Greece 2. Freshline Cosmetics, 1st km Lavriou Ave Koropiou—Markopoulou, GR-19400 Koropi, Greece 3. Bionos Biotech, S.L., ES-46026 Valencia, Spain 4. Institute of Applied Biosciences, CERTH, 6th km Charilaou-Thermis Road, P.O. Box 361, Thermi, GR-57001 Thessaloniki, Greece
Abstract
In the present study, selected cosmeceutical properties of aqueous extracts from the microalgae strain Trachydiscus minutus were assessed and compared with those obtained using three widely used Chlorella strains (C. vulgaris, C. sorokiniana, and C. minutissima). Among all extracts, T. minutus extracts showed the highest total antioxidant capacity (TAC) and inhibitory potency towards elastase, suggesting potential activity in controlling skin aging. Furthermore, the cytotoxicity, anti-inflammatory activity and UVA protection of T. minutus extract were evaluated employing normal human dermal fibroblasts (NHDF) and human keratinocyte HaCaT cells. The results showed that the T. minutus extract was able to significantly inhibit the transcription of selected marker genes involved in inflammation [interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor alpha (TNFα)]. In addition, treatment of NHDF and HaCaT cells with T. minutus extract ameliorate the UVA-induced cell damage by decreasing the accumulation of reactive oxygen species (ROS). Extracts from T. minutus were formulated into a skin care cream and an aqueous gel. Both formulas exhibited excellent compatibility and stability. Comprehensively, all these results suggest that T. minutus extract displays promising cosmeceutical properties by providing antioxidant, anti-aging, and anti-inflammatory activities, and therefore has potential for cosmeceutical use.
Funder
European Union’s Horizon 2020
Subject
Dermatology,Pharmaceutical Science,Aging,Chemical Engineering (miscellaneous),Surgery
Reference59 articles.
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