Sequential and Combined Efficacious Management of Auricular Keloid: A Novel Treatment Protocol Employing Ablative CO2 and Dye Laser Therapy—An Advanced Single-Center Clinical Investigation

Author:

Amato Simone1ORCID,Nisticò Steven Paul1,Pellacani Giovanni1,Guida Stefania23,Rossi Anthony4,Longo Caterina5,Berardesca Enzo6ORCID,Cannarozzo Giovanni7

Affiliation:

1. Dermatology Unit, Department of Clinical Internal Anesthesiologic Cardiovascular Sciences, Sapienza University of Rome, 00185 Rome, Italy

2. School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy

3. Dermatology Clinic, IRCCS San Raffaele Hospital, 20132 Milan, Italy

4. Department of Medicine, Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA

5. Department of Dermatology, University of Modena and Reggio Emilia, 41124 Modena, Italy

6. Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL 33136, USA

7. Unit of Dermatology, University of Rome Tor Vergata, 00133 Rome, Italy

Abstract

Auricular keloids pose significant aesthetic and functional challenges, and traditional treatments often fall short in addressing these issues. Our study presents an innovative combined approach of ablative CO2 and dye laser therapy for improved keloid management. This treatment protocol was applied to 15 patients with auricular keloids after an initial multispectral analysis to assess keloid composition. The laser sequence was tailored per patient based on this analysis. Evaluations using the Vancouver Scar Scale and Patient and Observer Scar Assessment Scale were carried out at baseline and at 3-week intervals post-treatment. The results showed a significant reduction in these scores at the final follow-up (p < 0.05), suggesting improvements in keloid color, texture, and pliability, with minimal adverse events. Additionally, no recurrence of keloids was observed. Our findings indicate that this novel methodology of multispectral analysis followed by tailored laser therapy may offer a safe and effective solution for auricular keloids, promising enhanced keloid treatment and prevention of recurrence. However, further investigations, including randomized controlled trials, are needed to confirm and optimize this treatment protocol.

Publisher

MDPI AG

Subject

Dermatology,Pharmaceutical Science,Aging,Chemical Engineering (miscellaneous),Surgery

Reference27 articles.

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2. Zhang, J., Zhou, S., Xia, Z., Peng, Z., and Yang, R. (2023, June 13). Fractional CO2 Laser Combined with 595-nm PDL Inhibiting Hypertrophic Scars via Measuring BMP-7 and Fas Expression in Rabbit Models. Available online: https://www.researchsquare.com/article/rs-120537/v1.

3. Advances in therapy of auricular keloid;Liu;Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2016

4. Quality of life of patients with keloid and hypertrophic scarring;Bock;Arch. Dermatol. Res.,2006

5. International clinical recommendations on scar management;Mustoe;Plast. Reconstr. Surg.,2002

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