Affiliation:
1. Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communication, Institute of Photonics Technology, Jinan University, Guangzhou 511443, China
Abstract
Peroxynitrite (ONOO−) is a highly reactive nitrogen species (RNS) that is closely associated with many physiological and pathological processes. In this study, we construct a near-infrared (NIR) fluorescent probe, NAF-BN, that utilizes benzyl boronic acid ester for fluorescence quenching of naphthofluorescein cores. NAF-BN has been thoroughly evaluated for reliable imaging of exogenous ONOO− in living cells. Further, NAF-BN can be applied effectively to visualize ONOO− in Drosophila brains, confirming the hypothesis that neonicotinoid pesticides increase neurological damage and oxidative stress. The probe NAF-BN offers exciting potential to reveal the role of ONOO− in various biological and medical fields.
Funder
Guangdong Special Support Plan
Guangdong Science and Technology Department
Guangzhou Municipal Science and Technology Project
Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program
Natural Science Foundation of Guangdong Province
National Natural Science Foundation of China
Youth Top-notch Scientific and Technological Innovation Talent of Guangdong Special Support Plan
Subject
Physical and Theoretical Chemistry,Analytical Chemistry
Cited by
1 articles.
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