Porphyrin Hetero-Trimer Involving a Hydrophilic and a Hydrophobic Structure with Application in the Fluorescent Detection of Toluidine Blue

Author:

Lascu Anca,Epuran Camelia,Fratilescu Ion,Birdeanu MihaelaORCID,Halip Liliana,Fagadar-Cosma EugeniaORCID

Abstract

The combination of a metallated porphyrin, Pt(II)-5,10,15,20-tetrakis-(4-allyloxyphenyl)-porphyrin (Pt-allyloxyPP), and a water-soluble porphyrin, 5,10,15,20-tetrakis(4-sulfonatophenyl)-porphyrin (TSPP), leads to the formation of a porphyrin hetero-trimer. The hetero-trimer, consisting of two TSPP molecules linked via oxygen atoms axially to the platinum atom in the Pt-allyloxyPP molecule, was characterized by UV–Vis, FT-IR, fluorescence, and 1H-NMR spectroscopy, and the proposed structure was confirmed. The new porphyrin hetero-trimer offers both the advantage of enhanced fluorescence and the presence of multiple sites for the detection of toluidine blue, due to its high affinity for acidic binding sites. This work brings attention to the purposely designed fluorescent sensor for toluidine blue, in the biologically relevant concentration domain of 1.9 × 10−6–6.39 × 10−5 M, with a very good accuracy.

Funder

Romanian Academy

Institute of Chemistry “Coriolan Dragulescu”

UEFISCDI

Publisher

MDPI AG

Subject

Physical and Theoretical Chemistry,Analytical Chemistry

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