Bioinspired Materials for Sensor and Clinical Applications: Two Case Studies

Author:

Alfinito Eleonora1ORCID,Ciccarese Mariangela2,Maruccio Giuseppe13ORCID,Monteduro Anna Grazia13ORCID,Rizzato Silvia13ORCID

Affiliation:

1. Department of Mathematics and Physics ‘Ennio De Giorgi’, University of Salento, I-73100 Lecce, Italy

2. Oncology Unit “Vito Fazzi” Hospital-Lecce, I-73100 Lecce, Italy

3. Omnics Research Group, CNR-Institute of Nanotechnology, INFN Sezione di Lecce, Via per Monteroni, I-73100 Lecce, Italy

Abstract

The growing interest in bio-inspired materials is driven by the need for increasingly targeted and efficient devices that also have a low ecological impact. These devices often use specially developed materials (e.g., polymers, aptamers, monoclonal antibodies) capable of carrying out the process of recognizing and capturing a specific target in a similar way to biomaterials of natural origin. In this article, we present two case studies, in which the target is a biomolecule of medical interest, in particular, α-thrombin and cytokine IL-6. In these examples, different biomaterials are compared to establish, with a theoretical-computational procedure known as proteotronics, which of them has the greatest potential for use in a biodevice.

Publisher

MDPI AG

Subject

Physical and Theoretical Chemistry,Analytical Chemistry

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