Abstract
Our knowledge on the plastic functions of the serotonin (5-HT) receptor subtype 7 (5-HT7R) in the brain physiology and pathology have advanced considerably in recent years. A wealth of data show that 5-HT7R is a key player in the establishment and remodeling of neuronal cytoarchitecture during development and in the mature brain, and its dysfunction is linked to neuropsychiatric and neurodevelopmental diseases. The involvement of this receptor in synaptic plasticity is further demonstrated by data showing that its activation allows the rescue of long-term potentiation (LTP) and long-term depression (LTD) deficits in various animal models of neurodevelopmental diseases. In addition, it is becoming clear that the 5-HT7R is involved in inflammatory intestinal diseases, modulates the function of immune cells, and is likely to play a role in the gut-brain axis. In this review, we will mainly focus on recent findings on this receptor’s role in the structural and synaptic plasticity of the mammalian brain, although we will also illustrate novel aspects highlighted in gastrointestinal (GI) tract and immune system.
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference117 articles.
1. Serotonin The Mediator that Spans Evolution;Pilowsky,2019
2. Serotonergic Neurons in Vertebrate and Invertebrate Model Organisms (Rodents, Zebrafish, Drosophila melanogaster, Aplysiacalifornica, Caenorhabditis elegans);Lillesaar,2019
3. Serotonergic neurotransmission manipulation for the understanding of brain development and function: Learning from Tph2 genetic models
4. Life Without Brain Serotonin: Phenotypes of Animals Deficient in Central Serotonin Synthesis;Mosienko,2019
5. The role of serotonin in memory: interactions with neurotransmitters and downstream signaling
Cited by
37 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献