Evaluation of the Methods for Nonlinear Analysis of Heart Rate Variability

Abstract

The dynamics of cardiac signals can be studied using methods for nonlinear analysis of heart rate variability (HRV). The methods that are used in the article to investigate the fractal, multifractal and informational characteristics of the intervals between heartbeats (RR time intervals) are: Rescaled Range, Detrended Fluctuation Analysis, Multifractal Detrended Fluctuation Analysis, Poincaré plot, Approximate Entropy and Sample Entropy. Two groups of people were studied: 25 healthy subjects (15 men, 10 women, mean age: 56.3 years) and 25 patients with arrhythmia (13 men, 12 women, mean age: 58.7 years). The results of the application of the methods for nonlinear analysis of HRV in the two groups of people studied are shown as mean ± std. The effectiveness of the methods was evaluated by t-test and the parameter Area Under the Curve (AUC) from the Receiver Operator Curve (ROC) characteristics. The studied 11 parameters have statistical significance (p < 0.05); therefore, they can be used to distinguish between healthy and unhealthy subjects. It was established by applying the ROC analysis that the parameters Hq=2(MFDFA), F(α)(MFDFA) and SD2(Poincaré plot) have a good diagnostic value; H(R/S), α1(DFA), SD1/SD2(Poincaré plot), ApEn and SampEn have a very good score; α2(DFA), αall(DFA) and SD1(Poincaré plot) have an excellent diagnostic score. In conclusion, the methods used for nonlinear analysis of HRV have been evaluated as effective, and with their help, new perspectives are opened in the diagnosis of cardiovascular diseases.