Exploring the Effects of Robertsonian Translocation 1/29 (Rob (1;29)) on Genetic Diversity in Minor Breeds of Spanish Berrenda Cattle via Genome-Wide Analysis

Author:

González-Cano Rafael12,González-Martínez Ana3ORCID,Ramón Manuel4ORCID,González Serrano Miriam3,Moreno Millán Miguel5,Rubio de Juan Alejandro2ORCID,Rodero Serrano Evangelina3ORCID

Affiliation:

1. Ministry of Agriculture, Fisheries and Food, Paseo Infanta Isabel 1, 28014 Madrid, Spain

2. Regional Center of Animal Breeding and Reproduction (CERSYRA-IRIAF), Avenida del Vino 10, 13300 Ciudad Real, Spain

3. Department of Animal Production, Faculty of Veterinary Sciences, University of Cordoba, 14071 Córdoba, Spain

4. Department of Animal Breeding and Genetics, National Institute for Agricultural and Food Research and Technology (INIA-CSIC), 28040 Madrid, Spain

5. Department of Genetic, Faculty of Veterinary Sciences, University of Cordoba, 14071 Córdoba, Spain

Abstract

Most of the previous studies on the genetic variability in Spanish “Berrenda” breeds have been carried out using DNA microsatellites. The present work aimed to estimate the genetic diversity, population structure, and potential genetic differences among individuals of both Berrenda breeds and groups based on the presence of the Robertsonian chromosomal translocation, rob (1;29). A total of 373 samples from animals belonging to the two breeds, including 169 cases diagnosed as rob (1;29)-positive, were genotyped using an SNP50K chip. The genetic diversity at the breed level did not show significant differences, but it was significantly lower in those subpopulations containing the rob (1;29). Runs of homozygosity identified a region of homozygosity on chromosome 6, where the KIT (KIT proto-oncogene, receptor tyrosine kinase) gene, which determines the typical spotted coat pattern in both breeds, is located. The four subpopulations considered showed minor genetic differences. The regions of the genome that most determined the differences between the breeds were observed on chromosomes 4, 6, 18, and 22. The presence of this Robertsonian translocation did not result in sub-structuring within each of the breeds considered. To improve the reproductive performance of Berrenda breeds, it would be necessary to implement strategies considering the involvement of potential breeding stock carrying rob (1;29).

Funder

IRIAF

UCO-ANABE Research Project

Publisher

MDPI AG

Reference57 articles.

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