Harnessing the Power of Venomous Animal-Derived Toxins against COVID-19-Reference-Cited by-同舟云学术

Harnessing the Power of Venomous Animal-Derived Toxins against COVID-19

Published:2023-02-14 Issue:2 Volume:15 Page:159
ISSN:2072-6651
Container-title:Toxins
language:en
Short-container-title:Toxins

Author:

Oliveira Isadora¹^ORCID,Ferreira Isabela¹^ORCID,Jacob Beatriz¹,Cardenas Kiara²,Cerni Felipe³,Baia-da-Silva Djane⁴⁵⁶⁷⁸,Arantes Eliane¹^ORCID,Monteiro Wuelton⁴⁵^ORCID,Pucca Manuela²³⁵^ORCID

Affiliation:

1. Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-903, SP, Brazil

2. Medical School, Federal University of Roraima, Boa Vista 69310-000, RR, Brazil

3. Health Sciences Postgraduate Program, Federal University of Roraima, Boa Vista 69310-000, RR, Brazil

4. Institute of Clinical Research Carlos Borborema, Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus 69850-000, AM, Brazil

5. Postgraduate Program in Tropical Medicine, School of Health Sciences, Amazonas State University, Manaus 69850-000, AM, Brazil

6. Department of Collective Health, Faculty of Medicine, Federal University of Amazonas, Manaus 69077-000, AM, Brazil

7. Leônidas and Maria Deane Institute, Fiocruz Amazônia, Manaus 69057-070, AM, Brazil

8. Faculty of Pharmacy, Nilton Lins University, Manaus 69058-040, AM, Brazil

Abstract

Animal-derived venoms are complex mixtures of toxins triggering important biological effects during envenomings. Although venom-derived toxins are known for their potential of causing harm to victims, toxins can also act as pharmacological agents. During the COVID-19 pandemic, there was observed an increase in in-depth studies on antiviral agents, and since, to date, there has been no completely effective drug against the global disease. This review explores the crosstalk of animal toxins and COVID-19, aiming to map potential therapeutic agents derived from venoms (e.g., bees, snakes, scorpions, etc.) targeting COVID-19.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundacão de Amparo à Pesquisa do Estado do Amazonas

FAPEAM

Publisher

MDPI AG

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

https://www.mdpi.com/2072-6651/15/2/159/pdf

Reference89 articles.

1. Utkin, Y., Siniavin, A., Kasheverov, I., and Tsetlin, V. (2022). Antiviral Effects of Animal Toxins: Is There a Way to Drugs?. Int. J. Mol. Sci., 23.

2. Global Epidemiology of HIV/AIDS: A Resurgence in North America and Europe;Govender;JEGH,2021

3. World Health Organization (2023, January 17). WHO Coronavirus (COVID-19) Dashboard. Available online: https://covid19.who.int.

4. The Growing Complexity of COVID-19 Drug and Vaccine Candidates: Challenges and Critical Transitions;Shariare;J. Infect. Public Health,2021

5. Animal Toxins—Nature’s Evolutionary-Refined Toolkit for Basic Research and Drug Discovery;Herzig;Biochem. Pharmacol.,2020