Efficacy of Feed Additive Containing Bentonite and Enzymatically Hydrolyzed Yeast on Intestinal Health and Growth of Newly Weaned Pigs under Chronic Dietary Challenges of Fumonisin and Aflatoxin

Author:

Deng Zixiao1,Jang Ki Beom1,Jalukar Sangita2,Du Xiangwei3,Kim Sung Woo1ORCID

Affiliation:

1. Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA

2. Arm & Hammer Animal and Food Production, Church & Dwight Co., Inc., Ewing, NJ 02628, USA

3. College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA

Abstract

This study aimed to investigate the efficacy of a feed additive containing bentonite and enzymatically hydrolyzed yeast on the intestinal health and growth of newly weaned pigs under chronic dietary exposure to fumonisin and aflatoxin. Newly weaned pigs were randomly allotted to one of four possible treatments: a control diet of conventional corn; a diet of corn contaminated with fumonisin and aflatoxin; a diet of mycotoxin-contaminated corn with 0.2% of feed additive; and a diet of mycotoxin contaminated corn with 0.4% of feed additive. We observed lower average weight gain and average daily feed intake in pigs that were fed only mycotoxin-contaminated corn compared to the control group. Feed additive supplementation linearly increased both average weight gain and feed intake, as well as tumor necrosis factor-alpha. In the jejunum, there was an observed decrease in immunoglobulin A and an increase in claudin-1. Additionally, feed additive supplementation increased the villus height to crypt depth ratio compared to the control. In conclusion, feed additives containing bentonite and enzymatically hydrolyzed yeast could mitigate the detrimental effects of mycotoxins on the growth performance of newly weaned pigs by improving intestinal integrity and positively modulating immune response.

Funder

North Carolina Agricultural Foundation

Church and Dwight Co., Inc.

Publisher

MDPI AG

Subject

Health, Toxicology and Mutagenesis,Toxicology

Reference73 articles.

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