Affiliation:
1. Xinjiang Key Laboratory of New Drug Study and Creation for Herbivorous Animals, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi 830052, China
2. College of Life Science, Yantai University, Yantai 264000, China
Abstract
Alternaria mycotoxins are a class of important, agriculture-related hazardous materials, and their contamination in ruminant feeds and products might bring severe toxic effects to animals and even human beings. To control these hazardous compounds, a reliable and sensitive LC-MS/MS (liquid chromatography–tandem mass spectrometry) method was established for simultaneous determination of six target Alternaria mycotoxins in ruminant feeds, including ALT (Altenuene), AME (Alternariol Monomethyl Ether), AOH (Alternariol), ATX-Ι (Altertoxins I), TeA (Tenuazonic Acid), and TEN (Tentoxin). This developed analytical method was used for the determination of the presence of these substances in cattle and sheep feeds in Xinjiang Province, China. The results revealed that Alternaria mycotoxins are ubiquitously detected in feed samples. Especially, AME, AOH, TeA, and TEN are the most frequently found mycotoxins with a positive rate over 40% and a concentration range of 4~551 µg/kg. The proposed method could be applied for exposure investigation of Alternaria mycotoxins in ruminant feeds and for the reduction in the health risk to animals and even consumers.
Funder
National Key Research and Development Program of China
Regional Fund of the National Natural Science Foundation of China
National Natural Science Foundation of China
Subject
Health, Toxicology and Mutagenesis,Toxicology
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