Air Pollution and microRNAs: The Role of Association in Airway Inflammation

Author:

Furci Fabiana1ORCID,Allegra Alessandro2ORCID,Tonacci Alessandro3ORCID,Isola Stefania4,Senna Gianenrico15ORCID,Pioggia Giovanni6ORCID,Gangemi Sebastiano4

Affiliation:

1. Allergy Unit and Asthma Center, Verona University Hospital, 37134 Verona, Italy

2. Division of Hematology, Department of Human Pathology in Adulthood and Childhood “Gaetano Barresi”, University of Messina, 98124 Messina, Italy

3. Clinical Physiology Institute, National Research Council of Italy (IFC-CNR), 56124 Pisa, Italy

4. School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy

5. Department of Medicine, Verona University Hospital, 37134 Verona, Italy

6. Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), 98164 Messina, Italy

Abstract

Air pollution exposure plays a key role in the alteration of gene expression profiles, which can be regulated by microRNAs, inducing the development of various diseases. Moreover, there is also evidence of sensitivity of miRNAs to environmental factors, including tobacco smoke. Various diseases are related to specific microRNA signatures, suggesting their potential role in pathophysiological processes; considering their association with environmental pollutants, they could become novel biomarkers of exposure. Therefore, the aim of the present work is to analyse data reported in the literature on the role of environmental stressors on microRNA alterations and, in particular, to identify specific alterations that might be related to the development of airway diseases so as to propose future preventive, diagnostic, and therapeutic strategies.

Publisher

MDPI AG

Subject

Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics

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