Chronic Stress Detrimentally Affects In Vivo Maturation in Rat Oocytes and Oocyte Viability at All Phases of the Estrous Cycle

Author:

Casillas FahielORCID,Betancourt Miguel,Juárez-Rojas Lizbeth,Ducolomb Yvonne,López Alma,Ávila-Quintero Alejandra,Zamora Jimena,Ommati Mohammad Mehdi,Retana-Márquez SocorroORCID

Abstract

Background: Stress has been considered as one of the causes of decreased reproductive function in women. However, direct evidence of the effect of chronic stress on oocytes depending on estrous cycle phases is limited. Objective: The present study aimed to evaluate the impact of chronic stress on the viability, integrity, and maturation of rat oocytes depending on estrous cycle phases, specifically proestrus, estrus, and diestrus. Methods: For this purpose, adult female rats were stressed daily by cold water immersion (15 °C) for 30 consecutive days. Results: In chronically stressed female rats, irregular estrous cyclicity, increased corticosterone levels, decreased oocyte viability, and an increased percentage of abnormal oocytes were obtained in all the estrous cycle phases, resulting in reduced oocyte maturation during proestrus. Conclusion: Oocyte maturation disturbed by chronic stress is a crucial factor by which chronic stress disrupts female reproduction

Funder

Consejo Nacional de Ciencia y Tecnología

Publisher

MDPI AG

Subject

General Veterinary,Animal Science and Zoology

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